Document Type
Article
Publication Date
4-2016
Publication Title
Journal of Biomedical Informatics
Volume
60
First Page
422
Last Page
430
Abstract
In cancer alternative RNA splicing represents one mechanism for flexible gene regulation, whereby protein isoforms can be created to promote cell growth, division and survival. Detecting novel splice junctions in the cancer transcriptome may reveal pathways driving tumorigenic events. In this regard, RNA-Seq, a high-throughput sequencing technology, has expanded the study of cancer transcriptomics in the areas of gene expression, chimeric events and alternative splicing in search of novel biomarkers for the disease.
DOI
https://doi.org/10.1016/j.jbi.2016.03.010
Recommended Citation
Rezaeian, Iman; Tavakoli, Ahmad; Cavallo-Medved, Dora; Porter, Lisa A.; and Rueda, Luis, "A novel model used to detect differential splice junctions as biomarkers in prostate cancer from RNA-Seq data" (2016). Journal of Biomedical Informatics, 60, 422-430.
https://scholar.uwindsor.ca/biologypub/106
Comments
The pipeline, along with their corresponding algorithms, are available upon request