Title

A novel model used to detect differential splice junctions as biomarkers in prostate cancer from RNA-Seq data

Document Type

Article

Publication Date

4-2016

Publication Title

Journal of Biomedical Informatics

Volume

60

First Page

422

Last Page

430

DOI

https://doi.org/10.1016/j.jbi.2016.03.010

Abstract

In cancer alternative RNA splicing represents one mechanism for flexible gene regulation, whereby protein isoforms can be created to promote cell growth, division and survival. Detecting novel splice junctions in the cancer transcriptome may reveal pathways driving tumorigenic events. In this regard, RNA-Seq, a high-throughput sequencing technology, has expanded the study of cancer transcriptomics in the areas of gene expression, chimeric events and alternative splicing in search of novel biomarkers for the disease.

Comments

The pipeline, along with their corresponding algorithms, are available upon request