A novel model used to detect differential splice junctions as biomarkers in prostate cancer from RNA-Seq data
Journal of Biomedical Informatics
In cancer alternative RNA splicing represents one mechanism for flexible gene regulation, whereby protein isoforms can be created to promote cell growth, division and survival. Detecting novel splice junctions in the cancer transcriptome may reveal pathways driving tumorigenic events. In this regard, RNA-Seq, a high-throughput sequencing technology, has expanded the study of cancer transcriptomics in the areas of gene expression, chimeric events and alternative splicing in search of novel biomarkers for the disease.
Rezaeian, Iman; Tavakoli, Ahmad; Cavallo-Medved, Dora; Porter, Lisa A.; and Rueda, Luis, "A novel model used to detect differential splice junctions as biomarkers in prostate cancer from RNA-Seq data" (2016). Journal of Biomedical Informatics, 60, 422-430.