Document Type

Article

Publication Date

2006

Publication Title

Biochemistry and Cell Biology

Volume

84

Issue

2

First Page

257

Last Page

262

DOI

10.1139/O06-036

Keywords

regeneration, Xenopus laevis, linib bud, Pitx1 protein, specification

Abstract

In contrast to the pattern of limb emergence in mammals, chicks, and the newt N. viridescens, embryos such as Xenopus laevis and Eleutherodactylus coqui initiate pelvic limb buds before they develop pectoral ones. We studied the expression of Pitx1 in X. laevis and E. coqui to determine if this paired-like homeodomain transcription factor directs differentiation specifically of the hindlinib, or if it directs the second pair of limbs to form, namely the forelimbs. We also undertook to determine if embryonic expression patterns were recapitulated during the regeneration of an amputated limb bud. Pitx1 is expressed in hindlimbs in both X. laevis and E. coqui, and expression is similar in both developing and regenerating limb buds. Expression in hindlimbs is restricted to regions of proliferating mesenchyme.

Comments

This article is available in its final form from NRC Research Press here: http://dx.doi.org/10.1139/o06-036.

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