Document Type

Article

Publication Date

2002

Publication Title

Biotechnology Advances

Volume

20

Issue

5

First Page

363

Last Page

378

DOI

10.1016/S0734-9750(02)00023-X

Keywords

developmental biology, array, genes

Abstract

Microarrays offer biologists comprehensive and powerful tools to analyze the involvement of genes in developmental processes at an unprecedented scale. Microarrays that employ defined sequences will permit us to elucidate genetic relationships and responses, while those that employ undefined DNA sequences (ESTs, cDNA, or genomic libraries) will help us to discover new genes, relate them to documented gene networks, and examine the way in which genes (and the process that they themselves control) are regulated. With access to broad new avenues of research come strategic and logistical headaches, most of which are embodied in the reams of data that are created over the course of an experiment. The solutions to these problems have provided interesting computational tools, which will allow us to compile huge data sets and to construct a genome-wide view of development. We are on the threshold of a new vista of possibilities where we might consider in comprehensive and yet specific detail, for example, the degree to which diverse organisms utilize similar genetic networks to achieve similar ends. (C) 2002 Elsevier Science Inc. All rights reserved.

Comments

“NOTICE: this is the author’s version of a work that was accepted for publication in Biotechnology Advances. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biotechnology Advances, 20 (5) http://dx.doi.org/10.1016/S0734-9750(02)00023-X.

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