Document Type
Article
Publication Date
11-2013
Publication Title
Organic Letters
Volume
15
Issue
21
First Page
5468
Last Page
5471
Abstract
Hexacarbonyldicobalt complexes of biaryl-substituted 4-methoxybutynones and 4-methoxy-2-butynes undergo intramolecular Nicholas reactions to form dibenzocyclooctyne–Co2(CO)6 complexes in good yields. Reductive decomplexation of the cyclization products is possible, and the method has been applied to a formal synthesis of isoschizandrin.
DOI
10.1021/ol402617a
Funding Reference Number
NSERC
Recommended Citation
Djurdjevic, Sinisa and Green, James R.. (2013). Nicholas Reactions in the Synthesis of Dicobalt Dibenzocyclooctyne Complexes. Organic Letters, 15 (21), 5468-5471.
https://scholar.uwindsor.ca/chemistrybiochemistrypub/71
Comments
This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Organic Letters, copyright © American Chemical Society after peer review. To access the final edited and published work see DOI: 10.1021/OL402617A at http://pubs.acs.org/doi/abs/10.1021/ol402617a.