Document Type

Article

Publication Date

11-2013

Publication Title

Organic Letters

Volume

15

Issue

21

First Page

5468

Last Page

5471

DOI

10.1021/ol402617a

Abstract

Hexacarbonyldicobalt complexes of biaryl-substituted 4-methoxybutynones and 4-methoxy-2-butynes undergo intramolecular Nicholas reactions to form dibenzocyclooctyne–Co2(CO)6 complexes in good yields. Reductive decomplexation of the cyclization products is possible, and the method has been applied to a formal synthesis of isoschizandrin.

Funding Reference Number

NSERC

Comments

This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Organic Letters, copyright © American Chemical Society after peer review. To access the final edited and published work see DOI: 10.1021/OL402617A at http://pubs.acs.org/doi/abs/10.1021/ol402617a.

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