Hexacarbonyldicobalt complexes of biaryl-substituted 4-methoxybutynones and 4-methoxy-2-butynes undergo intramolecular Nicholas reactions to form dibenzocyclooctyne–Co2(CO)6 complexes in good yields. Reductive decomplexation of the cyclization products is possible, and the method has been applied to a formal synthesis of isoschizandrin.
Funding Reference Number
Djurdjevic, Sinisa and Green, James R.. (2013). Nicholas Reactions in the Synthesis of Dicobalt Dibenzocyclooctyne Complexes. Organic Letters, 15 (21), 5468-5471.