Date of Award

2011

Degree Type

Thesis

Degree Name

M.A.Sc.

Department

Computer Science

First Advisor

Rueda, Luis (Computer Science)

Keywords

Computer science.

Rights

CC BY-NC-ND 4.0

Abstract

Prediction and discrimination of Crystal Packing interactions and Biological interactions is a particular problem that has drawn the attention of the research community in recent years. In this thesis, we have studied the prediction problem of these two types of interactions as well as obligate and nonobligate interactions. We are proposing new features such as Number Based Amino Acid Composition and Area Based Amino Acid Composition to predict different types of interactions more efficiently. We have measured our newly proposed features' contribution to the classification by comparing them with already proposed model. Along with we are also proposing an efficient multi-stage classification strategy to successfully predict crystal packing, non-obligate and obligate interactions. In this thesis we are also proposing a modified singularity problem free linear dimensionality reduction's linear transformation matrix maximization criterion. We have also applied our proposed LDR-Singular Value Decompositions modified (LDR-SVD) to other protein-protein interaction problems.

Share

COinS