Date of Award

1996

Degree Type

Thesis

Degree Name

M.Sc.

Department

Mathematics and Statistics

First Advisor

Fung, K.

Keywords

Statistics.

Rights

CC BY-NC-ND 4.0

Abstract

Quantitative risk assessment of noncarcinogens has been based on the estimation of the no-observed-adverse-effect-level (NOAEL). The NOAEL procedure has been shown to be unsatisfactory by many scientists. The fitting of dose-response models to teratology data involving littermates in order to estimate a teratogenic risk is becoming more popular as a potential alternative to the traditional approach to risk assessment. In this thesis a comparison of the different methods of risk assessment (NOAEL, ED$\sb{\alpha}$ and BMD$\sb{\alpha}$) are conducted through a simulation study and through real life developmental toxicity data. The estimates ED$\sb{\alpha}$ and BMD$\sb{\alpha}$ are computed with both the Dirichlet-trinomial and beta-binomial variance function, generalized linear model variance function and with the Rao-Scott transformation.Dept. of Mathematics and Statistics. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1996 .M375. Source: Masters Abstracts International, Volume: 37-01, page: 0280. Adviser: K. Fung. Thesis (M.Sc.)--University of Windsor (Canada), 1996.

Share

COinS