Myocyte and whole heart tissue phospholipid compositional changes following isoproterenol induced cardiac hypertrophy.

Date of Award


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Biology, Anatomy.




The effects of isoproternol (ISO) on the fatty acyl composition of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and a combined phosphatidylserine and phosphatidylinositol (PS + PI) fraction in both myocytes and whole heart tissue (WHT) of rats were examined following 0, 4 and 8 days of ISO injection. A myocardial hypertrophy of 24% resulted following 8 days of ISO treatment. The content of the individual phospholipids (PL) as well as total PL were increased at day 8. In WHT at day 8, ISO treatment resulted in a decrease in arachidonic acid in PC and the combined PS + PI fraction, an increase of stearic acid and a decrease in docosahexanoic acid in PC, an increase in oleic acid in PE, and a decrease in palmitic acid in PS + PI. In myocytes at day 8, ISO treatment resulted in an increase of oleic acid and a decrease of arachidonic acid in PC, an increase in palmitic acid in PE, and an increase in linoleic acid and a decrease in arachidonic acid of PS + PI. In addition, a comparison of the PL fatty acyl composition of the two tissue preparations revealed numerous differences occurring at day 0 and to some extent day 4. (Abstract shortened by UMI.)Dept. of Kinesiology. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1990 .B344. Source: Masters Abstracts International, Volume: 30-03, page: 0620. Thesis (M.H.K.)--University of Windsor (Canada), 1990.