Title

Myocyte and whole heart tissue phospholipid compositional changes following isoproterenol induced cardiac hypertrophy.

Date of Award

1990

Degree Type

Thesis

Degree Name

M.H.K.

Department

Kinesiology

Keywords

Biology, Anatomy.

Rights

CC BY-NC-ND 4.0

Abstract

The effects of isoproternol (ISO) on the fatty acyl composition of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and a combined phosphatidylserine and phosphatidylinositol (PS + PI) fraction in both myocytes and whole heart tissue (WHT) of rats were examined following 0, 4 and 8 days of ISO injection. A myocardial hypertrophy of 24% resulted following 8 days of ISO treatment. The content of the individual phospholipids (PL) as well as total PL were increased at day 8. In WHT at day 8, ISO treatment resulted in a decrease in arachidonic acid in PC and the combined PS + PI fraction, an increase of stearic acid and a decrease in docosahexanoic acid in PC, an increase in oleic acid in PE, and a decrease in palmitic acid in PS + PI. In myocytes at day 8, ISO treatment resulted in an increase of oleic acid and a decrease of arachidonic acid in PC, an increase in palmitic acid in PE, and an increase in linoleic acid and a decrease in arachidonic acid of PS + PI. In addition, a comparison of the PL fatty acyl composition of the two tissue preparations revealed numerous differences occurring at day 0 and to some extent day 4. (Abstract shortened by UMI.)Dept. of Kinesiology. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1990 .B344. Source: Masters Abstracts International, Volume: 30-03, page: 0620. Thesis (M.H.K.)--University of Windsor (Canada), 1990.