Date of Award
2014
Publication Type
Master Thesis
Degree Name
M.Sc.
Department
Biological Sciences
Keywords
Biological sciences
Supervisor
Zielinski, Barbara S.
Rights
info:eu-repo/semantics/openAccess
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Abstract
Serotonergic (5-hydroxytryptamine, 5-HT) fibers are distributed throughout the olfactory nerve and olfactory bulb of the sea lamprey. This study tested for 5-HT modulation of olfactory sensory responses to pheromone, amino acid and bile acid odours in the dorsal and lateral regions of the olfactory bulb by recording local field potentials. The peak amplitude of dorsal and lateral olfactory bulb responses to amino acid odours declined during 5-HT bath-application. The peak amplitude of responses to all odours increased during pharmacological blockade of the 5-HT1a receptor, but was not affected when 5-HT was added to the 5-HT1a antagonist, spiperone. The 5-HT1a antagonist, s(-)-uh-301, lengthened responses and had a larger number of peaks to all odours and spiperone lengthened responses and had a larger number of peaks to amino acids. We conclude that 5-HT attenuates odour responses in olfactory bulb via the 5HT1a receptor and suggest that 5-HT may also modulate olfactory-mediated behaviours.
Recommended Citation
Boyes, Karl C., "Serotonergic modulation of odour-evoked neural activity in the olfactory bulb of the sea lamprey (Petromyzon marinus)" (2014). Electronic Theses and Dissertations. 5062.
https://scholar.uwindsor.ca/etd/5062