Date of Award

2014

Degree Type

Thesis

Degree Name

M.Sc.

Department

Chemistry and Biochemistry

First Advisor

Pandey, Siyaram

Rights

CC BY-NC-ND 4.0

Abstract

Current chemotherapeutics have severe side effects due to non-specific targets that are present in all cells, such as DNA. Thus, there is a need for the development of alternative treatments with different, more specific targets. We have evaluated the efficacy of novel synthetic analogues of colchicine and curcumin. Colchicine is a natural compound used to treat gout. A small change in the structure of colchicine analogues led to different modes of action and selectivity. Curcumin is a natural compound with anti-cancer properties that is, unfortunately, associated with low bioavailability and requires high doses. Our curcumin analogues have remarkably high and selective activity against triple-negative human inflammatory breast cancer cells at a dose that is several fold lower than that of natural curcumin. These synthetic analogues open up new possibilities for the treatment of cancer.

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