Date of Award

2011

Degree Type

Thesis

Degree Name

M.A.Sc.

Department

Biological Sciences

First Advisor

Cohen, Jerome (Biological Sciences)

Keywords

Neurosciences.

Rights

CC BY-NC-ND 4.0

Abstract

Nissen and Bullemer (1987) developed the serial reaction time (SRT) task to measure attention in humans. The SRT task in rats is typically modeled after studies with humans and uses repeated or random sequences to test anticipatory reactions. In the current study, paraquat (PQ)-induced Parkinson's disease (PD) model in Long-Evans hooded rats was used to examine the rats' sequential learning. A water-soluble formulation of coenzyme Q10 (WS- CoQ10) was used as a therapeutic agent. Rats were induced with Parkinson's disease via the administration of paraquat. The aim of this study was to study the neuroprotective effects of CoQ10 using the SRT task to measure sequence performance in rats. The results indicated that the rats were much faster in responding to fixed sequences compared to random sequences. However, this study did not find significant results to indicate that exposure of paraquat with or without a neuroprotective agent, WS-CoQ10 affected serial reaction performance. The implications of these findings are discussed with suggestions for further research with this task.

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