Date of Award

2011

Degree Type

Thesis

Degree Name

M.A.Sc.

Department

Chemistry and Biochemistry

First Advisor

Pandey, Siyaram (Chemistry and Biochemistry)

Keywords

Biochemistry.

Rights

CC BY-NC-ND 4.0

Abstract

ABSTRACT Age-related neurodegenerative diseases are a major problem in industrialized nations, and affect millions of people worldwide. The pro-apoptotic protein Bax plays a crucial part in apoptosis. We screened a library of low molecular weight compounds for a potential Bax inhibitor. One compound that we have discovered (C22) was found to block Bax association to the mitochondria and prevent mitochondrial membrane destabilization. In addition, C22 may have the ability to prevent neuronal cell death in an in vivo model of stroke WS-CoQ10 is a potent anti-oxidant and is known to stabilize the mitochondria. The aim of this study was to evaluate the ability of WS-CoQ10 to the induction of stress-induced premature senescence in presenilin-1 (PS-1) mutated Alzheimer's Disease (AD) fibroblasts. It was found that WS-CoQ10 was able to inhibit senescence in these cells as well as decreasing the protein levels of senescence-associated proteins.

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