Document Type

Article

Publication Date

9-1-2023

Publication Title

Journal of Water and Health

Volume

21

Issue

9

First Page

1264

Keywords

MPOX, outbreak tracking, public health, viral partitioning, wastewater-based epidemiology

Last Page

1276

Abstract

Recent MPOX viral resurgences have mobilized public health agencies around the world. Recognizing the significant risk of MPOX outbreaks, large-scale human testing, and immunization campaigns have been initiated by local, national, and global public health authorities. Recently, traditional clinical surveillance campaigns for MPOX have been complemented with wastewater surveillance (WWS), building on the effectiveness of existing wastewater programs that were built to monitor SARS-CoV-2 and recently expanded to include influenza and respiratory syncytial virus surveillance in wastewaters. In the present study, we demonstrate and further support the finding that MPOX viral fragments agglomerate in the wastewater solids fraction. Furthermore, this study demonstrates that the current, most commonly used MPOX assays are equally effective at detecting low titers of MPOX viral signal in wastewaters. Finally, MPOX WWS is shown to be more effective at passively tracking outbreaks and/or resurgences of the disease than clinical testing alone in smaller communities with low human clinical case counts of MPOX.

DOI

10.2166/WH.2023.145

ISSN

14778920

E-ISSN

19967829

PubMed ID

37756194

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