Title

Exploring the Efficacy of Long Pepper and Sage Ethanolic Extracts for Inducing Selective Cell Death in Hodgkin Lymphoma Cell Lines

Prize Winner

Science

Streaming Media

Type of Proposal

Oral presentation

Start Date

29-3-2016 10:00 AM

End Date

29-3-2016 11:20 AM

Faculty

Faculty of Science

Faculty Sponsor

Dr. Pandey

Abstract

Cancer has become a persistent and unavoidable occurrence in today’s society. Forty percent of Canadians are expected to develop some type of cancer in their lifetime while a quarter of this group will eventually die to this disease. Current treatments such as chemotherapy, radiations, and many others are effective to some extent, but inadvertently cause severe side effects ranging from organ damage to death. Our aim is, through controlled laboratory experiments, to find a nontoxic and effective alternative to current treatments by examining the effects of natural health products on different cancer cells including Hodgkin lymphoma. Specifically we want to determine if sage and long pepper extracts have anti-cancer activity. We have observed that the ethanolic extracts of long pepper and sage are effective in reducing the viability of two Hodgkin lymphoma cell lines (L-540 and HD-MyZ) in a dose and time dependent manner. Furthermore, preliminary findings indicate a synergistic benefit of these extracts, when used in combination with each other. We have observed a combined effect on the induction of apoptosis when sub-lethal doses of these extracts were used for the treatment of Hodgkin lymphoma cell lines. These findings provide us with the background needed to further study these extracts, to determine whether they have the potential to be developed as safer anti-cancer agents for the treatment of cancer patients.

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Mar 29th, 10:00 AM Mar 29th, 11:20 AM

Exploring the Efficacy of Long Pepper and Sage Ethanolic Extracts for Inducing Selective Cell Death in Hodgkin Lymphoma Cell Lines

Cancer has become a persistent and unavoidable occurrence in today’s society. Forty percent of Canadians are expected to develop some type of cancer in their lifetime while a quarter of this group will eventually die to this disease. Current treatments such as chemotherapy, radiations, and many others are effective to some extent, but inadvertently cause severe side effects ranging from organ damage to death. Our aim is, through controlled laboratory experiments, to find a nontoxic and effective alternative to current treatments by examining the effects of natural health products on different cancer cells including Hodgkin lymphoma. Specifically we want to determine if sage and long pepper extracts have anti-cancer activity. We have observed that the ethanolic extracts of long pepper and sage are effective in reducing the viability of two Hodgkin lymphoma cell lines (L-540 and HD-MyZ) in a dose and time dependent manner. Furthermore, preliminary findings indicate a synergistic benefit of these extracts, when used in combination with each other. We have observed a combined effect on the induction of apoptosis when sub-lethal doses of these extracts were used for the treatment of Hodgkin lymphoma cell lines. These findings provide us with the background needed to further study these extracts, to determine whether they have the potential to be developed as safer anti-cancer agents for the treatment of cancer patients.