Title
Deadlock, a novel protein of Drosophila, is required for germline maintenance, fusome morphogenesis and axial patterning in oogenesis and associates with centrosomes in the early embryo
Document Type
Article
Publication Date
2006
Publication Title
Developmental Biology
Volume
294
Issue
2
First Page
406
Last Page
417
Abstract
The deadlock gene is required for a number of key developmental events in Drosophila oogenesis. Females homozygous for mutations in the deadlock gene lay few eggs and those exhibit severe patterning defects along both the anterior–posterior and dorsal–ventral axis. In this study, we analyzed eggs and ovaries from deadlock mutants and determined that deadlock is required for germline maintenance, stability of mitotic spindles, localization of patterning determinants, oocyte growth and fusome biogenesis in males and females. Deadlock encodes a novel protein which colocalizes with the oocyte nucleus at midstages of oogenesis and with the centrosomes of early embryos. Our genetic and immunohistological experiments point to a role for Deadlock in microtubule function during oogenesis.
DOI
10.1016/j.ydbio.2006.03.002
Recommended Citation
Wehr, Kristina; Swan, Andrew; and Schüpbach, Trudi, "Deadlock, a novel protein of Drosophila, is required for germline maintenance, fusome morphogenesis and axial patterning in oogenesis and associates with centrosomes in the early embryo" (2006). Developmental Biology, 294, 2, 406-417.
https://scholar.uwindsor.ca/biologypub/166