Title
Drosophila Female Meiosis and Embryonic Syncytial Mitosis Use Specialized Cks and CDC20 Proteins for Cyclin Destruction
Document Type
Article
Publication Date
2005
Publication Title
Cell Cycle
Volume
4
Issue
10
First Page
1332
Last Page
1334
Abstract
Female meiosis and the rapid mitotic cycle of early embryos are two non-canonical cell cycles that occur sequentially in the same cell, the egg, and utilize the same pool of cell cycle proteins. Using a genetic approach to identify genes that are specifically required for these cell cycles in Drosophila, we found that a Drosophila Cks gene, Cks30A is required for spindle assembly and anaphase progression in both female meiosis and in the syncytial embryo. Cks30A interacts with Cdk1 to target cyclin A for destruction in the female germline, possibly through the activation of a novel germline specific CDC20 protein, Cortex. These results indicate that anaphase progression in female meiosis and the early embryo are under unique control in Drosophila.
DOI
10.4161/cc.4.10.2088
Recommended Citation
Swan, Andrew and Schüpbach, Trudi, "Drosophila Female Meiosis and Embryonic Syncytial Mitosis Use Specialized Cks and CDC20 Proteins for Cyclin Destruction" (2005). Cell Cycle, 4, 10, 1332-1334.
https://scholar.uwindsor.ca/biologypub/167