Title
The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis
Document Type
Article
Publication Date
2008
Publication Title
CANCER RESEARCH
Volume
68
Issue
10
First Page
3591
Last Page
3600
Abstract
Spy1A is a unique cell cycle activator known to mediate cell cycle progression and override the DNA damage response. This study focused on determining the role of this protein on postnatal mammary gland morphogenesis and neoplasia. Herein, we show that Spy1A levels are tightly regulated during mammary gland development and that ectopic expression stimulates precocious development and results in disrupted morphology of the gland. This follows the same trend as the oncogene c-Myc, and we show that Spy1A expression is regulated downstream of c-Myc signaling. Importantly, we show that overexpression of Spy1A accelerates tumorigenesis in vivo. Collectively, this work is the first report that the Spy1/RINGO family of proteins may play an essential role in regulating both normal and abnormal growth processes in the breast.
DOI
10.1158/0008-5472.CAN-07-6453
Recommended Citation
Golipour, A.; Myers, Dorothy; Seagroves, Tiffany; Murphy, Daniel; Evan, Gerard I.; Donoghue, Daniel J.; Moorehead, Roger A.; and Porter, Lisa A., "The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis" (2008). CANCER RESEARCH, 68, 10, 3591-3600.
https://scholar.uwindsor.ca/biologypub/37