Plasma-associated halogenated phenolic contaminants in benthic and pelagic fish species from the Detroit River
Environmental Science and Technology
Halogenated phenolic contaminants (HPCs), polychlorinated biphenyls (PCBs), and other organochlorine (OC) contaminants (DDTs, chlordanes, HCH, and octachlorostyrene (OCS)) were determined (ng/g, wet wt. basis) in the blood plasma of 6 piscivorous/pelagic- and 7 benthicfeeding fish species from the Detroit River. Seven to twelve hydroxylated (OH) PCB congeners with pentachloro- to nonachloro-substitution, pentachlorophenol (PCP) and 4-OH-heptachlorostyrene (4-OH-HpCS), as well as a number of other unidentified HPCs, were detected in all the fish species studied. The concentrations of Σ-OH-PCB (0.57-129.5 ng/ g), 4-OH-HpCS (0.02-0.31 ng/g), and PCP (0.05-3.42 ng/ g) in comparison to other major polychlorinated contaminants (Σ-PCB (10.4-909.0 ng/g), Σ-chlordane (0.72-8.68 ng/g), Σ-DDT (2.10-66.57 ng/g), and Σ-HCH (0.04-0.84 ng/g)) demonstrate the importance of HPCs, especially OH-PCBs, as plasma-associated contaminants. OH-PCBs are most likely metabolites of PCBs, and 4-OH-HpCS is a likely metabolite of OCS. Our findings indicate that metabolic biotransformation is a factor in the bioaccumulation, pharmacokinetics, and fate of OCS and highly chlorinated PCB congeners that are generally more recalcitrant in fish. Target tissue exposure to circulating OH-PCBs was variable, and thus potential OH-PCB-mediated toxicological activity and effects (e.g., endocrine-related) and health risks are different among the fish species.
Li, H.; Drouillard, K. G.; Bennett, E.; Haffner, G. D.; and Letcher, R. J., "Plasma-associated halogenated phenolic contaminants in benthic and pelagic fish species from the Detroit River" (2003). Environmental Science and Technology, 37, 5, 832-839.