Title

Investigation of effects of the cosolvent methanol on the apparent solubility of a suite of chlorobenzenes using headspace solid-phase microextraction (HS-SPME)

Document Type

Article

Publication Date

2012

Publication Title

Journal of Chemical and Engineering Data

Volume

57

Issue

9

First Page

2373

Last Page

2378

DOI

10.1021/je300581n

Abstract

Cosolvent effects have historically been considered as negligible at cosolvent spiking concentrations below 1 %. Headspace solid-phase microextraction (HS-SPME) was used to determine the effect of the cosolvent methanol (MeOH) on apparent solubility of three chlorobenzenes (CBs) (1,2,4,5-tetrachlorobenzene, pentachlorobenzene, and hexachlorobenzene). All CBs exhibited a ln-linear decreasing relationship between cosolvent volume fraction and extracted mass. However, there were no statistical differences in measured headspace CB concentration at cosolvent additions of 1 % or less compared to controls. This study validated the use of MeOH volumes of 1 % and lower for batch studies using HS-SPME. Ninety-six hour incubation studies using 0.01 %, 10 %, and 100 % MeOH treatments demonstrated chemical losses from headspace vials through time. Declines were greatest for 0.01 % MeOH treatments and nonsignificant for vials containing 100 % MeOH. The silanization of vials using 5 % DCMCS was unsuccessful in reducing chemical loss; therefore potential loss processes must be further investigated prior to using the HS-SPME method for incubated treatments. © 2012 American Chemical Society.

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