Document Type


Publication Date


Publication Title

Canadian Journal of Chemistry


magnetic nanoparticles, cobalt-doped magnetite, antifungal activity, antibiotic


Nanoparticles, 10-14 nm, consisting of either Fe3O4 or Co0.2Fe2.8O4 stabilized with oleic acid, were prepared using solution combustion. Their structural and magnetic properties were examined using X-ray diffractometry, scanning electron microscopy, vibrating sample magnetometry, and Fourier-transform infrared spectroscopy. The properties of both sets of materials are similar except the cobalt-doped particles are considerably less magnetic. The in vitro inhibitory activities of the nanoparticles were assessed against pathogenic bacteria Shigella dysenteriae, Klebsiella pneumoniae, Acinetobacter baumannii, Streptococcus pyogenes, and pathogenic fungi and molds Candida albicans, Fusarium oxysporum and Aspergillus fumigatus. The magnetite nanoparticles were moderately effective against all tested pathogens, but the activity of the cobalt-doped nanoparticles was significantly lower, possibly due to an interruption of the Fenton reaction at the bacterial membrane. This work suggests that potentially doping magnetite with stronger metal oxidants may instead enhance their antimicrobial effects.



Funding Reference Number

NSERC, 2018-06338