Title

Characterization of self-assembled hybrid siloxane-phosphocholine bilayers

Document Type

Article

Publication Date

11-1-2018

Publication Title

Chemistry and Physics of Lipids

Volume

216

First Page

1

Last Page

8

DOI

10.1016/j.chemphyslip.2018.07.007

Keywords

Differential scanning calorimetry, Liposomes, Siloxane-phospholipid, Small angle X-ray scattering, Unilamellar vesicles

Abstract

© 2018 Elsevier B.V. We have synthesized six new hybrid siloxane phosphocholines (SiPCs) and examined their self-assembly behaviour in aqueous dispersions. Employing small angle X-ray scattering we have characterized SiPC bilayers. SiPCs exhibit differential self-assembly behaviour that results from the interplay between the siloxane fatty acid in the sn-2 position and the differing chain length fatty acids in the sn-1 position. SiPCs that possess a fatty acid chain of a C8–C14 chain length in the sn-1 position form unilamellar vesicles. Extending the fatty acid chain length to C16 and C18 allows for the formation of both unilamellar and multilamellar vesicles. We propose that the preferential formation of unilamellar vesicles is the result of an enhanced hydrophobic effect imparted by siloxane chains at the termini of lipid tails.

Share

COinS