Author ORCID Identifier
https://orcid.org/0000-0001-7334-9017 : Marcus Muresan
https://orcid.org/0000-0002-1585-5146 : Hariharaputhiran Subramanian
https://orcid.org/0000-0003-1999-4167 : Mukund P. Sibi
https://orcid.org/0000-0003-2334-4503 : James R. Green
European Journal of Organic Chemistry
Alkyne, Allene, Propargyl, Radicals, Synthetic methods
The appearance of propargyl radicals as synthetic intermediates has increased in recent years from a structural curiosity to a frequent occurrence. This minireview covers the synthetically relevant organic chemistry involving the intermediacy of propargyl radicals. The review is organized by the process employed in radical generation, including H-atom abstraction, propargyl-X homolyses, radical addition to enynes, reduction of polar C=X bonds, reductions of stable carbocations, and metal-mediated coupling reactions. The relevant mechanisms of generation and reaction are discussed, as are applications in syntheses of target molecules of interest.
Funding Reference Number
Muresan, Marcus; Subramanian, Hariharaputhiran; Sibi, Mukund P.; and Green, James R.. (2021). Propargyl Radicals in Organic Synthesis. European Journal of Organic Chemistry, 2021 (22), 3359-3375.
Available for download on Friday, August 19, 2022