Document Type
Article
Publication Date
11-7-2021
Publication Title
New Journal of Chemistry
Volume
45
Issue
41
First Page
19224
Last Page
19227
Abstract
This concise total synthesis of the Thomsen-Nouveau (Tn) glycoconjugate was accomplished using a palladium-catalyzed coupling between the glycosyl donor and Fmoc-protected serine acceptor. This is, to the best of our knowledge, the shortest synthesis reported from galactose for preparing this essential building block for large-scale solid phase peptide synthesis.
DOI
10.1039/d1nj01173a
ISSN
11440546
E-ISSN
13699261
Recommended Citation
Piazza, Sabrina M.; Reynolds, Michael R.; Chiaramonte, Jonathan; Xu, Peihan; Chapa-Villarreal, Fabiola A.; and Trant, John F.. (2021). Efficient and reproducible synthesis of an Fmoc-protected Tn antigen. New Journal of Chemistry, 45 (41), 19224-19227.
https://scholar.uwindsor.ca/chemistrybiochemistrypub/172