Adsorption, Air-liquid interface, Molecular dynamics, Monolayer, Phospholipids, Proteins, Pulmonary surfactant, Respiration, Squeeze-out, Surface tension
In this review, we delve into the topic of the pulmonary surfactant (PS) system, which is present in the respiratory system. The total composition of the PS has been presented and explored, from the types of cells involved in its synthesis and secretion, down to the specific building blocks used, such as the various lipid and protein components. The lipid and protein composition varies across species and between individuals, but ultimately produces a PS monolayer with the same role. As such, the composition has been investigated for the ways in which it imposes function and confers peculiar biophysical characteristics to the system as a whole. Moreover, a couple of theories/models that are associated with the functions of PS have been addressed. Finally, molecular dynamic (MD) simulations of pulmonary surfactant have been emphasized to not only showcase various group’s findings, but also to demonstrate the validity and importance that MD simulations can have in future research exploring the PS monolayer system.
Dziura, Maksymilian; Mansour, Basel; Dipasquale, Mitchell; Chandrasekera, P. Charukeshi; Gauld, James W.; and Marquardt, Drew. (2021). Simulated breathing: Application of molecular dynamics simulations to pulmonary lung surfactant. Symmetry, 13 (7).