alkynes, total synthesis, carbocation, fused-ring systems, electrophilic aromatic substitution, transition metals
The synthesis of the Cinnamomum homosesquiterpenoid tenuifolin has been accomplished by way of an intramolecular Nicholas reaction of the [Co2(CO)6] complex of an alkyne-substituted biaryl for construction of the seven-membered ring. The cyclization features the reaction of a nonactivated arene ring with the propargyldicobalt cation to give the dibenzocycloheptyne-Co2(CO)6.
Funding Reference Number
Djurdjevic, Sinisa and Green, James R.. (2014). Synthesis of Tenuifolin via Intramolecular Nicholas Reaction. Synlett, 25 (17), 2467-2470.