Factors Affecting Critical Toxicokinetic Parameters of Polychlorinated Biphenyls (PCBS) in Japanese Koi (CYPRINUS CARPIO): Effect of Diet on Chemical Assimilation and Influence of Feces to Whole Body Chemical Elimination
Date of Award
Great Lakes Institute for Environmental Research
Drouillard, Kenneth (GLIER)
CC BY-NC-ND 4.0
This thesis provides enhanced calibration of critical parameters, chemical uptake efficiency (AE), chemical whole body elimination rate coefficient (ktot), and fecal elimination rate coefficients (kex), which are applied in a generalized fish bioaccumulation model applicable to polychlorinated biphenyls. Chapter 2 presents measurements of chemical AE based on a mass balance method and shows that both chemical hydrophobicity and diet properties have a significant influence on the chemical AE. Lipid content in the diet was not shown to have significant effect on the chemical AE. Chapter 3 provides measurements of ktot and kex for both labile and recalcitrant PCB congeners across three dose levels. First order kinetics was confirmed in the study, which also showed that fecal elimination counted for only a small fiction of the whole body elimination. Gill elimination and metabolic biotransformation were shown to be equally important as elimination routes for labile congeners.
Liu, Jian, "Factors Affecting Critical Toxicokinetic Parameters of Polychlorinated Biphenyls (PCBS) in Japanese Koi (CYPRINUS CARPIO): Effect of Diet on Chemical Assimilation and Influence of Feces to Whole Body Chemical Elimination" (2009). Electronic Theses and Dissertations. 366.