Date of Award


Publication Type

Master Thesis

Degree Name



Biological Sciences


Biology, Genetics.




Natural house mouse (Mus domesticus) populations were screened for Y-specific DNA restriction fragment length polymorphisms. Y-specific DNA restriction fragments were detected using a biotinylated YDNA probe and a nonradioactive detection system. Hybridization of the YDNA probe to female inbred mouse DNA was not detected. Y-specific DNA sequence variation was not detected in natural house mouse populations of southwestern Ontario. The Y-specific DNA sequences detected were identical to those observed in the inbred mouse strains studied. Two situations may explain the lack of detection of Y-specific DNA variability in these mouse populations. First, considerable Y-specific DNA sequence variation may exist but was not detected. Second, Y-specific DNA variability may be infrequent in the mouse populations analyzed. Considering the methods, the former seems unlikely. Low frequency of variation in Y-specific DNA sequences may result either from the loss of new neutral mutations in large populations or in small populations having high levels of gene flow or from strong selective pressures. Considering the small effective population size for Y-linked alleles and the population structuring of these mouse populations, strong selective pressures appear to be the most likely explanation. (Abstract shortened by UMI.)Dept. of Biological Sciences. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1990 .H555. Source: Masters Abstracts International, Volume: 30-03, page: 0635. Thesis (M.Sc.)--University of Windsor (Canada), 1990.