Date of Award


Publication Type

Master Thesis

Degree Name



Chemistry and Biochemistry

First Advisor

Pandey, Siyaram



Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.


Current chemotherapeutics have severe side effects due to non-specific targets that are present in all cells, such as DNA. Thus, there is a need for the development of alternative treatments with different, more specific targets. We have evaluated the efficacy of novel synthetic analogues of colchicine and curcumin. Colchicine is a natural compound used to treat gout. A small change in the structure of colchicine analogues led to different modes of action and selectivity. Curcumin is a natural compound with anti-cancer properties that is, unfortunately, associated with low bioavailability and requires high doses. Our curcumin analogues have remarkably high and selective activity against triple-negative human inflammatory breast cancer cells at a dose that is several fold lower than that of natural curcumin. These synthetic analogues open up new possibilities for the treatment of cancer.