Date of Award
Chemistry and Biochemistry
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Current chemotherapeutics have severe side effects due to non-specific targets that are present in all cells, such as DNA. Thus, there is a need for the development of alternative treatments with different, more specific targets. We have evaluated the efficacy of novel synthetic analogues of colchicine and curcumin. Colchicine is a natural compound used to treat gout. A small change in the structure of colchicine analogues led to different modes of action and selectivity. Curcumin is a natural compound with anti-cancer properties that is, unfortunately, associated with low bioavailability and requires high doses. Our curcumin analogues have remarkably high and selective activity against triple-negative human inflammatory breast cancer cells at a dose that is several fold lower than that of natural curcumin. These synthetic analogues open up new possibilities for the treatment of cancer.
Larocque, Kristen Elizabeth, "Anti-Cancer Properties of Synthetic Analogues of the Natural Compounds Colchicine and Curcumin" (2014). Electronic Theses and Dissertations. 5182.