Date of Award

2012

Publication Type

Master Thesis

Degree Name

M.Sc.

Department

Chemistry and Biochemistry

First Advisor

Siyaram Pandey

Keywords

Coenzyme Q10, Dopamine, Dopaminergic, Parkinson's Disease, Substantia Nigra, Water-Soluble Coenzyme Q10

Rights

info:eu-repo/semantics/openAccess

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Abstract

Parkinson's disease is a common neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain. Mitochondrial dysfunction and oxidative stress are major contributors to this disease. Currently there is no treatment to halt the progression of Parkinson's disease; there are only drugs for symptomatic relief. Previously, prophylactic treatment with a water-soluble formulation of coenzyme Q

10 was shown to reduce the loss of dopaminergic neurons in the substantia nigra and ameliorate symptoms in a paraquat-induced rat model of Parkinson's disease. In this work, delivery of CoQ

10 by the water-soluble formulation shows increased bioavailability in various rat tissues, including the brain. Also observed is a decrease in the loss of dopaminergic neurons in the substantia nigra by therapeutic water-soluble CoQ

10 supplementation in a rat model. Hence, this formulation of CoQ

10 may be used to slow or halt the progression of Parkinson's disease.

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