case-control data, multiallele, linkage disequilibrium
This paper considers the analysis of genetic case-control data. We consider the allele frequency in cases and controls. Because each individual has two alleles at any autosomal locus, there will be twice as many alleles as people in the allele distribution. Simultaneously, the serological distribution is bulit by ignoring the difference between homozygous and herterozygous. We also consider the marker loci with multiple alleles. Traditional case-control studies provide a powerful and efficient method for evaluation of association between candidate gene and disease. There has been debate on how the power of tests for association changes with different allelic effect. To facilitate the design of association studies, we present power and sample size formulas for Armitage's test for trend applied to case-control studies of candidate genes.
Master of Science
Mathematics and Statistics
Major Research Paper