Title

Effects of concommitant denervation and re-amputation through the regenerative forelimb outgrowth of Xenopus laevis froglets.

Document Type

Article

Publication Date

1986

Publication Title

Canadian Journal of Zoology

Volume

64

Issue

1

First Page

258

Last Page

262

DOI

10.1139/z86-041

Abstract

Normally innervated Xenopus laevis froglet forelimbs respond to amputational injury by forming a heteromorphic, cartilaginous spike outgrowth. However, denervation concomitant with amputation of the distal portion of a regenerate outgrowth performed at 1, 2, 3, 4, and 6 weeks after initial forelimb amputation resulted in the regression (resorption) of most, if not all, of the remaining portion of the regenerate tissues. These results indicate that, as in urodele amphibians, concomitantly denervated and amputated forelimb outgrowths of postmetamorphic froglets do not adjust sufficiently to denervation and fresh amputation to allow regeneration to recommence. Instead, progressive resorption of the remaining tissues of the regenerate occurs.

Comments

The final version of this article is available from NRC Research Press here: http://dx.doi.org/10.1139/z86-041.