Modulating NF-κB Activity as a Therapeutic Strategy against Lymphoma with Analogs of Curcumin
Type of Proposal
Oral presentation
Faculty
Faculty of Science
Faculty Sponsor
Siyaram Pandey
Proposal
It is estimated that 2 in 5 Canadians will develop cancer in their lifetimes and 1 in 4 will die of this disease. Lymphoma is the fifth most common cancer in Canada and it has the fastest raising incident rate in young adults. Current cancer treatment includes chemotherapy, surgery and radiation. The majority of chemotherapeutics target DNA or tubulin, which is not selective against cancer cells. One possible target for lymphoma is the increased expression and activation of the nuclear transcription factor NF-κB. This protein causes the expression of cell cycle and cell survival genes. Curcumin is isolated from Tumeric root, which has already shown to target NF-κB and selectively induce apoptosis in cancer cells. Curcumin has a low bioavailability but this problem can be solved with a synthetic analog. Our objective is to determine if any of our ten Curcumin analogs have the anti-cancer activity. Two of these analogs that have shown anti-cancer activity and have been evaluated with the WST-1 metabolic assay and the Annexin V binding assay for apoptosis. Further illustration of the mechanism is needed. These compounds seem to target non-genomic metabolic targets and have a potential for non-toxic cancer treatment.
Start Date
29-3-2016 4:00 PM
End Date
29-3-2016 5:00 PM
Modulating NF-κB Activity as a Therapeutic Strategy against Lymphoma with Analogs of Curcumin
It is estimated that 2 in 5 Canadians will develop cancer in their lifetimes and 1 in 4 will die of this disease. Lymphoma is the fifth most common cancer in Canada and it has the fastest raising incident rate in young adults. Current cancer treatment includes chemotherapy, surgery and radiation. The majority of chemotherapeutics target DNA or tubulin, which is not selective against cancer cells. One possible target for lymphoma is the increased expression and activation of the nuclear transcription factor NF-κB. This protein causes the expression of cell cycle and cell survival genes. Curcumin is isolated from Tumeric root, which has already shown to target NF-κB and selectively induce apoptosis in cancer cells. Curcumin has a low bioavailability but this problem can be solved with a synthetic analog. Our objective is to determine if any of our ten Curcumin analogs have the anti-cancer activity. Two of these analogs that have shown anti-cancer activity and have been evaluated with the WST-1 metabolic assay and the Annexin V binding assay for apoptosis. Further illustration of the mechanism is needed. These compounds seem to target non-genomic metabolic targets and have a potential for non-toxic cancer treatment.