Title
Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCFTIR1 in Mediating Auxin Response
Document Type
Article
Publication Date
2001
Publication Title
Science
Volume
292
Issue
5520
First Page
1379
Last Page
1382
Abstract
The COP9 signalosome is an evolutionary conserved multiprotein complex of unknown function that acts as a negative regulator of photomorphogenic seedling development in Arabidopsis. Here, we show that plants with reduced COP9 signalosome levels had decreased auxin response similar to loss-of-function mutants of the E3 ubiquitin ligase SCFTIR1. Furthermore, we found that the COP9 signalosome and SCFTIR1 interacted in vivo and that the COP9 signalosome was required for efficient degradation of PSIAA6, a candidate substrate of SCFTIR1. Thus, the COP9 signalosome may play an important role in mediating E3 ubiquitin ligase–mediated responses.
DOI
10.1126/science.1059776
Recommended Citation
Schwechheimer, Claus; Serino, Giovanna; Callis, Judy; Crosby, William L.; Lyapina, Svetlana; Deshaies, Raymond J.; Gray, William M.; Estelle, Mark; and Deng, Xing-Wang, "Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCFTIR1 in Mediating Auxin Response" (2001). Science, 292, 5520, 1379-1382.
https://scholar.uwindsor.ca/biologypub/1000