"Investigation of effects of the cosolvent methanol on the apparent sol" by K. N. McPhedran, R. Seth et al.
 

Investigation of effects of the cosolvent methanol on the apparent solubility of a suite of chlorobenzenes using headspace solid-phase microextraction (HS-SPME)

Document Type

Article

Publication Date

2012

Publication Title

Journal of Chemical and Engineering Data

Volume

57

Issue

9

First Page

2373

Last Page

2378

Abstract

Cosolvent effects have historically been considered as negligible at cosolvent spiking concentrations below 1 %. Headspace solid-phase microextraction (HS-SPME) was used to determine the effect of the cosolvent methanol (MeOH) on apparent solubility of three chlorobenzenes (CBs) (1,2,4,5-tetrachlorobenzene, pentachlorobenzene, and hexachlorobenzene). All CBs exhibited a ln-linear decreasing relationship between cosolvent volume fraction and extracted mass. However, there were no statistical differences in measured headspace CB concentration at cosolvent additions of 1 % or less compared to controls. This study validated the use of MeOH volumes of 1 % and lower for batch studies using HS-SPME. Ninety-six hour incubation studies using 0.01 %, 10 %, and 100 % MeOH treatments demonstrated chemical losses from headspace vials through time. Declines were greatest for 0.01 % MeOH treatments and nonsignificant for vials containing 100 % MeOH. The silanization of vials using 5 % DCMCS was unsuccessful in reducing chemical loss; therefore potential loss processes must be further investigated prior to using the HS-SPME method for incubated treatments. © 2012 American Chemical Society.

DOI

10.1021/je300581n

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