Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer

Authors

Nisha Anand
Sabita Murthy
Gudrun Amann
Meredith Wernick
Lisa A. Porter, University of WindsorFollow
I. Howard Cukier
Colin Collins
Joe W. Gray
Joachim Diebold
Doug J. Demetrick
Jonathan M. Lee

Document Type

Article

Publication Date

2002

Publication Title

Nature Genetics

Volume

31

Issue

3

First Page

301

Last Page

305

Abstract

We have found that EEF1A2, the gene encoding protein elongation factor EEF1A2 (also known as eEF-12), is amplified in 25% of primary ovarian tumors and is highly expressed in approximately 30% of ovarian tumors and established cell lines. We have also demonstrated that EEF1A2 has oncogenic properties: it enhances focus formation, allows anchorage-independent growth and decreases the doubling time of rodent fibroblasts. In addition, EEF1A2 expression made NIH3T3 fibroblasts tumorigenic and increased the growth rate of ES-2 ovarian carcinoma cells xenografted in nude mice. Thus, EEF1A2 and the process of protein elongation are likely to be critical in the development of ovarian cancer.

DOI

10.1038/ng904

Recommended Citation

Anand, Nisha; Murthy, Sabita; Amann, Gudrun; Wernick, Meredith; Porter, Lisa A.; Cukier, I. Howard; Collins, Colin; Gray, Joe W.; Diebold, Joachim; Demetrick, Doug J.; and Lee, Jonathan M., "Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer" (2002). Nature Genetics, 31, 3, 301-305.
https://scholar.uwindsor.ca/biologypub/782