Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer
We have found that EEF1A2, the gene encoding protein elongation factor EEF1A2 (also known as eEF-12), is amplified in 25% of primary ovarian tumors and is highly expressed in approximately 30% of ovarian tumors and established cell lines. We have also demonstrated that EEF1A2 has oncogenic properties: it enhances focus formation, allows anchorage-independent growth and decreases the doubling time of rodent fibroblasts. In addition, EEF1A2 expression made NIH3T3 fibroblasts tumorigenic and increased the growth rate of ES-2 ovarian carcinoma cells xenografted in nude mice. Thus, EEF1A2 and the process of protein elongation are likely to be critical in the development of ovarian cancer.
Anand, Nisha; Murthy, Sabita; Amann, Gudrun; Wernick, Meredith; Porter, Lisa A.; Cukier, I. Howard; Collins, Colin; Gray, Joe W.; Diebold, Joachim; Demetrick, Doug J.; and Lee, Jonathan M., "Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer" (2002). Nature Genetics, 31, 3, 301-305.