Title

Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer

Document Type

Article

Publication Date

2002

Publication Title

Nature Genetics

Volume

31

Issue

3

First Page

301

Last Page

305

DOI

10.1038/ng904

Abstract

We have found that EEF1A2, the gene encoding protein elongation factor EEF1A2 (also known as eEF-12), is amplified in 25% of primary ovarian tumors and is highly expressed in approximately 30% of ovarian tumors and established cell lines. We have also demonstrated that EEF1A2 has oncogenic properties: it enhances focus formation, allows anchorage-independent growth and decreases the doubling time of rodent fibroblasts. In addition, EEF1A2 expression made NIH3T3 fibroblasts tumorigenic and increased the growth rate of ES-2 ovarian carcinoma cells xenografted in nude mice. Thus, EEF1A2 and the process of protein elongation are likely to be critical in the development of ovarian cancer.

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