Developing Human-Nonhuman Chimeras in Human Stem Cell Research: Ethical Issues and Boundaries

Document Type

Article

Publication Date

2005

Publication Title

Kennedy Institute of Ethics Journal

Volume

15

Issue

2

First Page

107

Last Page

134

Abstract

The transplantation of adult human neural stem cells into prenatal non-humans offers an avenue for studying human neural cell development without direct use of human embryos. However, such experiments raise significant ethical concerns about mixing human and nonhuman materials in ways that could result in the development of human-nonhuman chimeras. This paper examines four arguments against such research, the moral taboo, species integrity, "unnaturalness," and human dignity arguments, and finds the last plausible. It argues that the transfer of human brain or retinal stem cells to nonhuman embryos would not result in the development of human-nonhuman chimeras that denigrate human dignity, provided such stem cells are dissociated. The article provides guidelines that set ethical boundaries for conducting such research that are consonant with the requirements of human dignity.

DOI

10.1353/ken.2005.0015

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