Document Type
Article
Publication Date
1999
Publication Title
Genes & Development
Volume
13
Issue
13
First Page
1678
Last Page
1691
Abstract
The plant hormone auxin regulates diverse aspects of plant growth and development. We report that in Arabidopsis, auxin response is dependent on a ubiquitin-ligase (E3) complex called SCFTIR1. The complex consists of proteins related to yeast Skp1p and Cdc53p called ASK and AtCUL1, respectively, as well as the F-box protein TIR1. Mutations in either ASK1 or TIR1 result in decreased auxin response. Further, overexpression of TIR1 promotes auxin response suggesting that SCFTIR1 is limiting for the response. These results provide new support for a model in which auxin action depends on the regulated proteolysis of repressor proteins.
Recommended Citation
Gray, William M.; del Pozo, J. Carlos; Walker, Loni; Hobbie, Lawrence; Risseeuw, Eddy; Banks, Travis; Crosby, William L.; Yang, Ming; Ma, Hong; and Estelle, Mark, "Identification of an SCF ubiquitin–ligase complex required for auxin response in Arabidopsis thaliana" (1999). Genes & Development, 13, 13, 1678-1691.
https://scholar.uwindsor.ca/biologypub/995