Efficient and reproducible synthesis of an Fmoc-protected Tn antigen

Authors

Sabrina M. Piazza, University of Windsor
Michael R. Reynolds, University of Windsor
Jonathan Chiaramonte, University of Windsor
Peihan Xu, University of Windsor
Fabiola A. Chapa-Villarreal, University of Windsor
John F. Trant, University of Windsor

Document Type

Article

Publication Date

11-7-2021

Publication Title

New Journal of Chemistry

Volume

45

Issue

41

First Page

19224

Last Page

19227

Abstract

This concise total synthesis of the Thomsen-Nouveau (Tn) glycoconjugate was accomplished using a palladium-catalyzed coupling between the glycosyl donor and Fmoc-protected serine acceptor. This is, to the best of our knowledge, the shortest synthesis reported from galactose for preparing this essential building block for large-scale solid phase peptide synthesis.

DOI

10.1039/d1nj01173a

ISSN

11440546

E-ISSN

13699261

Recommended Citation

Piazza, Sabrina M.; Reynolds, Michael R.; Chiaramonte, Jonathan; Xu, Peihan; Chapa-Villarreal, Fabiola A.; and Trant, John F.. (2021). Efficient and reproducible synthesis of an Fmoc-protected Tn antigen. New Journal of Chemistry, 45 (41), 19224-19227.
https://scholar.uwindsor.ca/chemistrybiochemistrypub/172