Document Type
Article
Publication Date
11-1-2021
Publication Title
Chemistry and Physics of Lipids
Volume
241
Keywords
Lipid volume, Liposomes, Mixed chain lipids, Neutron scattering, Siloxane phospholipid, X-ray scattering
Abstract
Siloxanes are molecules used extensively in commercial, industrial, and biomedical applications. The inclusion of short siloxane chains into phospholipids results in interesting physical properties, including the ability to form low polydispersity unilamellar vesicles. As such, hybrid siloxane phosphocholines (SiPCs) have been examined as a potential platform for the delivery of therapeutic agents. Using small angle X-ray and neutron scattering, vibrating tube densitometry, and differential scanning calorimetry, we studied four hybrid SiPCs bilayers. Lipid volume measurements for the different SiPCs compared well with those previously determined for polyunsaturated PCs. Furthermore, the different SiPC's membrane thicknesses increased monotonically with temperature and, for the most part, consistent with the behavior observed in unsaturated lipids such as, 1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine and 1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine, and the branched lipid 1,2-diphytanoyl-sn-glyerco-3-phosphocholine (DPhyPC).
DOI
10.1016/j.chemphyslip.2021.105149
ISSN
00093084
E-ISSN
18732941
Recommended Citation
Frampton, Mark B.; Yakoub, Doruntina; Katsaras, John; Zelisko, Paul M.; and Marquardt, Drew. (2021). A calorimetric, volumetric and combined SANS and SAXS study of hybrid siloxane phosphocholine bilayers. Chemistry and Physics of Lipids, 241.
https://scholar.uwindsor.ca/chemistrybiochemistrypub/292
PubMed ID
34627769