Dimyristoyl phosphatidylcholine: A remarkable exception to α-tocopherol's membrane presence
Document Type
Article
Publication Date
1-8-2014
Publication Title
Journal of the American Chemical Society
Volume
136
Issue
1
First Page
203
Last Page
210
Abstract
Using data obtained from different physical techniques (i.e., neutron diffraction, NMR and UV spectroscopy), we present evidence which explains some of the conflicting and inexplicable data found in the literature regarding α-tocopherol's (aToc's) behavior in dimyristoyl phosphatidylcholine (di-14:0PC) bilayers. Without exception, the data point to aToc's active chromanol moiety residing deep in the hydrophobic core of di-14:0PC bilayers, a location that is in stark contrast to aToc's location in other PC bilayers. Our result is a clear example of the importance of lipid species diversity in biological membranes and importantly, it suggests that measurements of aToc's oxidation kinetics, and its associated byproducts observed in di-14:0PC bilayers, should be reexamined, this time taking into account its noncanonical location in this bilayer. © 2013 American Chemical Society.
DOI
10.1021/ja408288f
ISSN
00027863
E-ISSN
15205126
Recommended Citation
Marquardt, Drew; Williams, Justin A.; Kinnun, Jacob J.; Kučerka, Norbert; Atkinson, Jeffrey; Wassall, Stephen R.; Katsaras, John; and Harroun, Thad A.. (2014). Dimyristoyl phosphatidylcholine: A remarkable exception to α-tocopherol's membrane presence. Journal of the American Chemical Society, 136 (1), 203-210.
https://scholar.uwindsor.ca/chemistrybiochemistrypub/316
PubMed ID
24308426