The “Nitrogen Effect”: Complexation with Macrocycles Potentiates Fused Heterocycles to Form Halogen Bonds in Competitive Solvents

Authors

Dr. Kwaku Twum, Department of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan
Sanaz Nadimi, Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario
Frank Boateng Osei, Department of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan
Dr. Rakesh Puttreddy, Department of Chemistry, University of Jyvaskyla, Survontie 9 B, FI-40014 Jyvaskyla
Dr. Yvonne Bessem Ojong, Department of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan
Dr. John J. Hayward, Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario
Prof. Kari Rissanen, Department of Chemistry, University of Jyvaskyla, Survontie 9 B, FI-40014 Jyvaskyla
Prof. John F. Trant, Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario
Prof. Ngong Kodiah Beyeh Kodiah BeyehFollow

Author ORCID Identifier

https://orcid.org/0000-0001-5390-0609 : Kwaku Twum

https://orcid.org/0000-0002-6028-6480 : Sanaz Nadimi

https://orcid.org/0000-0003-0223-7602 : Frank Boateng Osei

https://orcid.org/0000-0002-2221-526X : Rakesh Puttreddy

https://orcid.org/0000-0002-1208-5051 : Yvonne Bessem Ojong

https://orcid.org/0000-0002-7502-7780 : John Hayward

https://orcid.org/0000-0002-7282-8419 : Kari Rissanen

https://orcid.org/0000-0002-4780-4968 : John F. Trant

https://orcid.org/0000-0003-3935-1812 : Ngong Kodiah Beyeh

Document Type

Article

Publication Date

1-27-2023

Publication Title

Chemistry: An Asian Journal

Volume

18

Issue

6

First Page

e202201308

Abstract

Weak intermolecular forces are typically very difficult to observe in highly competitive polar protic solvents as they are overwhelmed by the quantity of competing solvent. This is even more challenging for three-component ternary assemblies of pure organic compounds. In this work, we overcome these complications by leveraging the binding of fused aromatic N-heterocycles in an open resorcinarene cavity to template the formation of a three-component halogen-bonded ternary assembly in a protic polar solvent system.

DOI

10.1002/asia.202201308

ISSN

1861-4728

Recommended Citation

Twum, Dr. Kwaku; Nadimi, Sanaz; Osei, Frank Boateng; Puttreddy, Dr. Rakesh; Ojong, Dr. Yvonne Bessem; Hayward, Dr. John J.; Rissanen, Prof. Kari; Trant, Prof. John F.; and Beyeh, Prof. Ngong Kodiah Beyeh Kodiah. (2023). The “Nitrogen Effect”: Complexation with Macrocycles Potentiates Fused Heterocycles to Form Halogen Bonds in Competitive Solvents. Chemistry: An Asian Journal, 18 (6), e202201308.
https://scholar.uwindsor.ca/chemistrybiochemistrypub/338