Date of Award
Chemistry and Biochemistry
Mutus, Bulent (Chemistry and Biochemistry)
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Platelet aggregation is a complex process that results in side effects for patients with diabetes, atherosclerosis, stroke and heart attack. Although thoroughly studied, the details of the aggregation cascade are not determined. The mechanism for participation of protein disulfide isomerase (PDI) in platelet function has received attention in literature however has not been established. In addition, heat shock protein 70 (Hsp70) was found on the platelet surface and was investigated for its role in platelet aggregation. Thymosin was of interest as a potential effector in platelet aggregation. An additional goal of the study was further optimization of the flow cell chamber platelet aggregation model. UV-VIS Spectrophotometric and flow cell chamber data that indicate no significant effect of excess platelet surface PDI, b-b or Hsp70 on platelet aggregation and adhesion. However, Thymosin has been shown to positively affect rates of platelet aggregation at the doses of 1-10 g/mL.
Heeney, Rebecca, "The Effects of Cell Surface Proteins and Redox State on Platelet Aggregation and Adhesion" (2010). Electronic Theses and Dissertations. 304.