Date of Award
1998
Publication Type
Doctoral Thesis
Degree Name
Ph.D.
Department
Biological Sciences
Keywords
Biology, Cell.
Supervisor
Dufresne, M. J.
Rights
info:eu-repo/semantics/openAccess
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Abstract
The results reported in this dissertation provide evidence that the cysteine protease, cathepsin B, is one of the nonmuscle-specific genes expressed in a regulated manner during myogenesis. Unlike muscle-specific enzymes such as creatine phosphokinase (CPK), levels of cathepsin B activity are high in dividing, presumptive myoblasts. As these cells align in linear arrays in preparation for fusion, levels of cathepsin B activity drop dramatically and then increase in a fusion-related manner characteristic of muscle specific enzymes. This current studies appears to be the first to demonstrate a "down-up" pattern of cathepsin B activity over the entire differentiation process in vitro and to provide both indirect and direct evidence for the role of cathepsin B in myogenesis. Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 0659. Adviser: Michael J. DuFresne. Thesis (Ph.D.)--University of Windsor (Canada), 1998.
Recommended Citation
Jane, Derek Thomas, "The role and regulation of cathepsin B during skeletal muscle cell differentiation" (1998). Electronic Theses and Dissertations. 4234.
https://scholar.uwindsor.ca/etd/4234
