Date of Award
2016
Publication Type
Doctoral Thesis
Degree Name
Ph.D.
Department
Chemistry and Biochemistry
Keywords
Amino acids, Nitrogen-14, Pharmaceuticals, Polymorphs, Solid-state NMR, Ultra-wideline
Supervisor
Schurko, Robert
Rights
info:eu-repo/semantics/openAccess
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Abstract
Nitrogen is an important element in all areas of chemistry, biology, and materials science. However, it is challenging to probe directly with solid-state nuclear magnetic resonance (SSNMR). The commonly studied isotope, 15N (nuclear spin, I, = ½), has a low natural abundance (0.36%); therefore, 15N NMR experiments often require isotopically enriched samples. 14N (I = 1) has a high natural abundance (99.64%) but is a quadrupolar nucleus. 14N SSNMR spectra are generally very broad due to the moderate quadrupole moment of 14N. Ultra-wideline (UW) 14N SSNMR spectra have very low signal-to-noise, which complicates their acquisition; however, they are useful probes of molecular-level structure and dynamics, and do not require isotopic enrichment for their acquisition.
Recommended Citation
Veinberg, Stanislav L., "Natural Abundance 14N and 15N Solid-State NMR Studies of Organic, Biochemical, and Pharmaceutical Systems" (2016). Electronic Theses and Dissertations. 5771.
https://scholar.uwindsor.ca/etd/5771