Date of Award
L. R. Sabina
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Previously, Ara-A has been found to be an effective antiviral agent against DNA virus infections. In this study, antiviral activity was shown against an RNA virus, vesicular stomatitis virus. The inhibitory effect of Ara-A was found to occur early during virus replication. Cycloheximide, puromycin, and radioisotope incorporation experiments showed that Ara-A seems to stimulate protein synthesis while depressing RNA synthesis. The exact mode of action of Ara-A remains unclear, however some speculation concerning this problem is reported herein.
Grant, John A., "The antiviral activity of 9-β-D-arabinofuranosyl adenine against vesicular stomatitis virus" (1971). Electronic Theses and Dissertations. 8023.