Date of Award

1971

Publication Type

Master Thesis

Degree Name

M.Sc.

Department

Biological Sciences

First Advisor

L. R. Sabina

Keywords

Biological sciences

Rights

info:eu-repo/semantics/openAccess

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Abstract

Previously, Ara-A has been found to be an effective antiviral agent against DNA virus infections. In this study, antiviral activity was shown against an RNA virus, vesicular stomatitis virus. The inhibitory effect of Ara-A was found to occur early during virus replication. Cycloheximide, puromycin, and radioisotope incorporation experiments showed that Ara-A seems to stimulate protein synthesis while depressing RNA synthesis. The exact mode of action of Ara-A remains unclear, however some speculation concerning this problem is reported herein.

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