Partial Volumes of Phosphatidylcholines and Vitamin E: α-Tocopherol Prefers Disordered Membranes

Authors

Mitchell Dipasquale, University of Windsor
Michael H.L. Nguyen, University of Windsor
Georg Pabst, Universitat Graz
Drew Marquardt, University of Windsor

Document Type

Article

Publication Date

9-8-2022

Publication Title

Journal of Physical Chemistry B

Volume

126

Issue

35

First Page

6691

Last Page

6699

Abstract

Despite its discovery over 95 years ago, the biological and nutritional roles of vitamin E remain subjects of much controversy. Though it is known to possess antioxidant properties, recent assertions have implied that vitamin E may not be limited to this function in living systems. Through densitometry measurements and small-angle X-ray scattering we observe favorable interactions between α-tocopherol and unsaturated phospholipids, with more favorable interactions correlating to an increase in lipid chain unsaturation. Our data provide evidence that vitamin E may preferentially associate with oxygen sensitive lipids-an association that is considered innate for a viable membrane antioxidant.

DOI

10.1021/acs.jpcb.2c04209

ISSN

15206106

E-ISSN

15205207

Recommended Citation

Dipasquale, Mitchell; Nguyen, Michael H.L.; Pabst, Georg; and Marquardt, Drew. (2022). Partial Volumes of Phosphatidylcholines and Vitamin E: α-Tocopherol Prefers Disordered Membranes. Journal of Physical Chemistry B, 126 (35), 6691-6699.
https://scholar.uwindsor.ca/chemistrybiochemistrypub/284

PubMed ID

36027485