Title
Partial Volumes of Phosphatidylcholines and Vitamin E: α-Tocopherol Prefers Disordered Membranes
Document Type
Article
Publication Date
9-8-2022
Publication Title
Journal of Physical Chemistry B
Volume
126
Issue
35
First Page
6691
Last Page
6699
Abstract
Despite its discovery over 95 years ago, the biological and nutritional roles of vitamin E remain subjects of much controversy. Though it is known to possess antioxidant properties, recent assertions have implied that vitamin E may not be limited to this function in living systems. Through densitometry measurements and small-angle X-ray scattering we observe favorable interactions between α-tocopherol and unsaturated phospholipids, with more favorable interactions correlating to an increase in lipid chain unsaturation. Our data provide evidence that vitamin E may preferentially associate with oxygen sensitive lipids-an association that is considered innate for a viable membrane antioxidant.
DOI
10.1021/acs.jpcb.2c04209
ISSN
15206106
E-ISSN
15205207
Recommended Citation
Dipasquale, Mitchell; Nguyen, Michael H.L.; Pabst, Georg; and Marquardt, Drew. (2022). Partial Volumes of Phosphatidylcholines and Vitamin E: α-Tocopherol Prefers Disordered Membranes. Journal of Physical Chemistry B, 126 (35), 6691-6699.
https://scholar.uwindsor.ca/chemistrybiochemistrypub/284
PubMed ID
36027485