α-Tocopherols location in membranes is not affected by their composition
Document Type
Article
Publication Date
4-21-2015
Publication Title
Langmuir
Volume
31
Issue
15
First Page
4464
Last Page
4472
Abstract
To this day, α-tocopherols (aToc) role in humans is not well known. In previous studies, we have tried to connect aTocs biological function with its location in a lipid bilayer. In the present study, we have determined, by means of small-angle neutron diffraction, that not only is aTocs hydroxyl group located high in the membrane but its tail also resides far from the center of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) bilayers. In addition, we located aTocs hydroxyl group above the lipid backbone in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine (POPS), and sphingomyelin bilayers, suggesting that aTocs location near the lipid-water interface may be a universal property of vitamin E. In light of these data, how aToc efficiently terminates lipid hydroperoxy radicals at the membrane center remains an open question.
DOI
10.1021/la502605c
ISSN
07437463
E-ISSN
15205827
Recommended Citation
Marquardt, Drew; Kučerka, Norbert; Katsaras, John; and Harroun, Thad A.. (2015). α-Tocopherols location in membranes is not affected by their composition. Langmuir, 31 (15), 4464-4472.
https://scholar.uwindsor.ca/chemistrybiochemistrypub/312
PubMed ID
25317847