Date of Award
4-18-2024
Publication Type
Thesis
Degree Name
M.Sc.
Department
Chemistry and Biochemistry
Keywords
Cancer;Drug-drug Interaction (DDI);Matcha Green tea extract;Natural Health Products;Rosemary extract;White tea extract
Supervisor
Siyaram Pandey
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
Cancer presents an enormous global disease burden as one of the leading causes of death from non-infectious disease worldwide. Perhaps even more challenging than the enormous strain it places on national healthcare systems is the treatment of the disease – or more accurately, the lack of effective, safe, precise, and broadly applicable treatments. Commonly used conventional therapeutic options are often only applicable and effective in a small subset of cancers, and within that scope are further limited in their effectiveness to a subset of patients. They also have numerous toxic side-effects due to non-selectivity or due to their mechanisms of action. Natural plant extracts, which have multiple bioactive compounds that act via different pathways, have displayed robust anti-cancer activity in previous research. Herein, an understanding of the challenges and burden imposed by cancer, it’s underlying pathology, various treatments utilized currently in treating the disease, various natural extracts and compounds and their specific anti-cancer effects in a variety of cancer types and subtypes are all presented and expounded. Furthermore, the results of in-vitro and in-vivo analyses of two novel extracts (Rosemary and Synthite tea) and a previously characterized extract (White tea) not yet tested in colorectal cancer (CRC) were studied in relation to their potential anti-cancer activity in two CRC models. The results indicated that RE, STE, and WT selectively reduce cell viability in-vitro to varying degrees of potency. RE and WT reduce cell viability via apoptosis, and RE showed a mild to moderate ability to reduce growth of HT-29 CRC tumours without causing any significant level of toxicity to mice.
Recommended Citation
Scaria, Benjamin, "Investigation of the anti-cancer activity of multiple novel proprietary, and previously characterized natural extracts in multiple colorectal cancer models: Efficacy in targeting human colorectal cancer cells, and analysis and toxicology of in-vivo response" (2024). Electronic Theses and Dissertations. 9442.
https://scholar.uwindsor.ca/etd/9442